Notch signaling is a highly conserved cellular signaling pathway that plays a critical role in various developmental processes, including cell fate determination, proliferation, differentiation, and maintenance of stem cell populations. The pathway is activated by the binding of Notch receptors to ligands on neighboring cells, leading to proteolytic cleavage of the Notch receptor and translocation of the intracellular domain into the nucleus. Once in the nucleus, the intracellular domain interacts with transcription factors to regulate the expression of target genes that control cell fate and differentiation. Dysregulation of Notch signaling has been implicated in a variety of diseases, including cancer, cardiovascular disorders, and neurological disorders. Research in the field of Notch signaling aims to further understand the molecular mechanisms underlying this pathway and its role in development and disease.